Goserelin

What it is

Goserelin (Zoladex) is a synthetic GnRH agonist administered as a subcutaneous implant depot. It is FDA-approved for prostate cancer (advanced disease and locally advanced disease as adjunct to radiation), advanced breast cancer in pre/perimenopausal women, endometriosis, and endometrial thinning before endometrial ablation.

Mechanism of action

Same GnRH agonist mechanism as leuprolide and triptorelin. The implant formulation provides slow release over 1 or 3 months depending on the specific implant.

Approved indications

• Advanced prostate cancer
• Locally advanced prostate cancer with radiation
• Advanced breast cancer in pre/perimenopausal women
• Endometriosis
• Endometrial thinning before ablation

Why this is out of scope at The Tide

Specialty oncology and gynecology medication appropriately prescribed by the relevant specialty. Implant insertion requires specific clinical training. The Tide does not provide oncology or specialty gynecologic care.

Where to learn more

Urologic oncology, medical oncology, or gynecology depending on indication.