Cathelicidins
Antimicrobial peptide class.
What it is
Cathelicidins are a family of antimicrobial peptides characterized by a conserved cathelin pro-domain that is cleaved to release the active antimicrobial fragment. Humans have a single cathelicidin (hCAP-18) that is processed to release LL-37, the only active human cathelicidin peptide.
This entry serves as a reference for the broader cathelicidin family. For clinical use, see the LL-37 entry, which represents the active human cathelicidin we prescribe.
Mechanism of action
Cathelicidins work through similar mechanisms as other antimicrobial peptides: membrane disruption, biofilm activity, and immunomodulation. The activity profile varies by species and specific cathelicidin.
Clinical evidence
The cathelicidin family has been extensively studied. Most clinical evidence relates to LL-37 specifically — see the LL-37 entry for clinical evidence and use details.
Why we don’t prescribe non-LL-37 cathelicidins at The Tide
LL-37 is the human cathelicidin and is the appropriate clinical option in this peptide class. Non-human cathelicidins are research compounds without clinical pharmacy availability or established protocols.
Where to learn more
See the LL-37 entry for comprehensive clinical information about cathelicidin therapy at The Tide.