Desmopressin
Synthetic vasopressin analog for diabetes insipidus and bleeding disorders.
What it is
Desmopressin (DDAVP, Stimate) is a synthetic vasopressin analog with selective V2 receptor activity (water reabsorption) and minimal V1 activity (vasoconstriction). The selectivity makes it useful for diabetes insipidus and bleeding disorders without the vasopressor effects of native vasopressin. It is FDA-approved for several specific indications.
Mechanism of action
Selective V2 receptor activation increases renal water reabsorption (the antidiuretic effect) and increases circulating von Willebrand factor and Factor VIII levels (the hemostatic effect).
Approved indications
- Central diabetes insipidus
- Primary nocturnal enuresis in children
- Hemophilia A (mild)
- von Willebrand disease (Type 1)
Why this is out of scope at The Tide
Specialty medication for endocrine, urologic, and hematologic conditions. Diabetes insipidus is managed by endocrinology. Bleeding disorders are managed by hematology. Pediatric enuresis is managed by pediatrics or pediatric urology. Not appropriate for outpatient peptide clinic.
Where to learn more
The relevant specialty for the indication: endocrinology, hematology, or urology.