Palmitoyl tripeptide-1
Cosmetic collagen-stimulating peptide.
What it is
Palmitoyl tripeptide-1 (PAL-GHK) is a cosmetic peptide consisting of glycyl-histidyl-lysine (the same tripeptide as GHK-Cu but without copper) attached to a palmitic acid molecule for enhanced skin penetration. It is marketed as a collagen-stimulating ingredient in topical skincare.
Mechanism of action
The GHK sequence is hypothesized to support fibroblast activity and collagen synthesis when delivered topically. The palmitoyl modification enhances penetration through the stratum corneum.
Use as cosmetic ingredient
Formulated into topical anti-aging skincare products, often combined with palmitoyl tetrapeptide-7 (Matrixyl 3000 combination).
Why this is out of scope at The Tide
This is a cosmetic skincare ingredient appropriately addressed through dermatology, aesthetic medicine, or skincare retail. For clinical (medical) skin applications, see our GHK-Cu entry, which we do prescribe.
Where to learn more
Dermatology and aesthetic providers, evidence-based skincare publications.