Defensins
Alpha/beta defensins
Class of endogenous antimicrobial peptides. No FDA-approved drug product.
Also known as · Orbactiv · Kimyrsa
Oritavancin
Single-dose lipoglycopeptide for skin infections.
What it is
Oritavancin (Orbactiv, Kimyrsa) is a single-dose lipoglycopeptide antibiotic; the brand-name products Orbactiv and Kimyrsa are FDA-approved for acute bacterial skin and skin structure infections caused by susceptible gram-positive organisms. The very long half-life allows complete treatment with a single dose.
Mechanism of action
Inhibits bacterial cell wall synthesis. Active against gram-positive organisms including MRSA. The very long half-life (~245 hours) supports single-dose treatment regimens.
Approved indications
Acute bacterial skin and skin structure infections.
Why this is out of scope at The Tide
IV antibiotic for serious infections, administered in hospital or infusion-center settings under appropriate physician care. Not appropriate for an outpatient clinic.
Where to learn more
Infectious disease, emergency medicine, or hospital-based providers.
Related peptides
From the same category.
LL-37
Cathelicidin
The only known human cathelicidin antimicrobial peptide. Not FDA-approved; investigational.