Defensins
Alpha/beta defensins
Class of endogenous antimicrobial peptides. No FDA-approved drug product.
Also known as · Cubicin
Daptomycin
Cyclic lipopeptide antibiotic for gram-positive infections.
What it is
Daptomycin (Cubicin) is a cyclic lipopeptide antibiotic; the brand-name product Cubicin is FDA-approved for treatment of complicated skin and soft tissue infections, S. aureus bacteremia, and right-sided endocarditis caused by gram-positive organisms.
Mechanism of action
Daptomycin binds bacterial cell membranes in a calcium-dependent manner, causing membrane depolarization and cell death. The mechanism is distinct from other antibiotic classes and provides utility against multidrug-resistant gram-positive organisms including MRSA and VRE.
Approved indications
- Complicated skin and soft tissue infections
- S. aureus bacteremia
- Right-sided S. aureus endocarditis
Why this is out of scope at The Tide
IV antibiotic for serious infections requiring hospital or infusion-center administration with appropriate monitoring. Infectious disease consultation typical for indications requiring daptomycin. Not appropriate for an outpatient clinic.
Where to learn more
Infectious disease specialists.
Related peptides
From the same category.
LL-37
Cathelicidin
The only known human cathelicidin antimicrobial peptide. Not FDA-approved; investigational.