Daptomycin
Cyclic lipopeptide antibiotic for gram-positive infections.
What it is
Daptomycin (Cubicin) is a cyclic lipopeptide antibiotic FDA-approved for treatment of complicated skin and soft tissue infections, S. aureus bacteremia, and right-sided endocarditis caused by gram-positive organisms.
Mechanism of action
Daptomycin binds bacterial cell membranes in a calcium-dependent manner, causing membrane depolarization and cell death. The mechanism is distinct from other antibiotic classes and provides utility against multidrug-resistant gram-positive organisms including MRSA and VRE.
Approved indications
- Complicated skin and soft tissue infections
- S. aureus bacteremia
- Right-sided S. aureus endocarditis
Why this is out of scope at The Tide
IV antibiotic for serious infections requiring hospital or infusion-center administration with appropriate monitoring. Infectious disease consultation typical for indications requiring daptomycin. Not appropriate for outpatient peptide clinic.
Where to learn more
Infectious disease specialists.